Toll-like receptors as potential therapeutic targets for multiple diseases
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Updated: Sep 29, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
Claudia Zuany-Amorim1, John Hastewell, Christoph Walker
1Novartis Horsham Research Centre, Novartis Pharmaceutical Ltd, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK.
Abstract:
The family of Toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through their ability to recognize pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as microbial components, are recognized by TLRs, and that small-molecular-mass synthetic compounds activate TLRs, raised interest in these receptors as potential targets for the development of new therapies for multiple diseases. In this review, we discuss the current and future use of TLR agonists or antagonists in chronic inflammatory diseases and highlight potential problems that are associated with such approaches.
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