Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic renal dysfunction late after liver transplantation.

Ari J Cohen1, Mark D Stegall, Charles B Rosen

  • 1Department of Surgery, Division of Transplantation, Mayo Clinic, Rochester, MN 55905, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|October 3, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline Tumor-Specific Prognosis in Early-Stage Hepatocellular Carcinoma: Time-Dependent Role of Biomarker Profile and Modified ALBI Grade.

Cancers·2026
Same author

Abdominal Arterial Calcification as an Imaging Biomarker of Mortality in Kidney Transplant Waitlist Patients.

Nephrology (Carlton, Vic.)·2026
Same author

Pathomic analysis of 5-year surveillance biopsies as predictors of kidney allograft loss.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Longitudinal Peripheral Blood Transcriptomics Reveal Novel Signatures During Cardiac Allograft Rejection.

Transplantation direct·2026
Same author

Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease.

Kidney international reports·2025
Same author

Living Paired Exchange Donation: Unlocking New Horizons in Kidney Transplantation.

Mayo Clinic proceedings·2025

Renal dysfunction is a common late complication after liver transplantation. A glomerular filtration rate (GFR) below 40 mL/min/BSA at 1 year post-transplant indicates high risk for kidney failure.

Area of Science:

  • Nephrology
  • Hepatology
  • Transplantation Medicine

Background:

  • Liver transplantation success has increased, leading to a rise in late complications like renal dysfunction.
  • Assessing long-term renal function post-liver transplant is crucial for patient outcomes.

Purpose of the Study:

  • To determine the prevalence of renal dysfunction years after liver transplantation.
  • To identify risk factors for developing renal dysfunction post-liver transplant.

Main Methods:

  • Retrospective analysis of 527 liver transplantations (1990-1998).
  • Glomerular filtration rate (GFR) measured by iothalamate clearance pre- and post-transplantation.
  • Intensive follow-up for 191 patients with GFR measurements at 1 and 3 years.

Related Experiment Videos

Main Results:

  • Overall mean GFR was acceptable and similar between tacrolimus and cyclosporine immunosuppression.
  • Renal dysfunction was progressive; 27.5% had GFR < 40 mL/min/BSA at 5 years.
  • Pre-transplant GFR did not predict late renal function, but 1-year GFR was a strong predictor.
  • Cumulative incidence of renal failure was 6.25% at 7 years and 10% at 10 years.

Conclusions:

  • Renal dysfunction is a significant late complication following liver transplantation.
  • One-year post-transplant GFR is the best predictor of long-term renal function.
  • Patients with low 1-year GFR (< 40 mL/min/BSA) require early intervention to prevent renal failure.