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Published on: September 12, 2019
[Development and long-term prognosis of unexplained persistent inflammatory biologic syndromes]
A E Perrin1, B Goichot, E Andrès
1Service de médecine interne et nutrition, hôpital de Hautepierre, avenue Molière, 67098 Strasbourg, France. anne-elisabeth.perrin@chru-strasbourg.fr
La Revue De Medecine Interne
|October 4, 2002
Summary
Long-term follow-up of unexplained inflammatory syndrome shows a good prognosis. Most patients experienced spontaneous resolution or received a diagnosis and treatment, with persistence not indicating a poor outcome.
Area of Science:
- Internal Medicine
- Clinical Research
Context:
- Unexplained inflammatory syndrome is a common concern in internal medicine.
- Long-term outcomes for these patients are not well-documented.
- This study addresses the need for understanding the prognosis of undiagnosed inflammatory syndromes.
Purpose:
- To describe the long-term follow-up and prognosis of patients hospitalized for inflammatory syndrome without a definitive diagnosis.
- To evaluate the clinical course and outcomes in this patient cohort.
Summary:
- A retrospective study of 46 patients (1992-1999) with unexplained inflammatory syndrome.
- One-third showed spontaneous resolution, one-third received a later diagnosis (often chronic inflammatory diseases), and one-third had persistent, asymptomatic syndrome.
- The overall prognosis was favorable.
Impact:
- Suggests that persistent inflammatory syndrome without a diagnosis is not a poor prognostic indicator.
- Recommends clinical and biological follow-up over repeated etiological investigations for such patients.
- Informs clinical management strategies for unexplained inflammatory conditions.
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