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The IMGT/HLA sequence database.

J Robinson1, S G Marsh

  • 1Anthony Nolan Research Institute, London, UK.

Reviews in Immunogenetics
|October 4, 2002
PubMed
Summary
This summary is machine-generated.

The IMGT/HLA database provides a comprehensive resource for human leukocyte antigen (HLA) gene sequences, crucial for understanding transplantation and disease susceptibility. It offers tools for analysis and submission of new HLA allele data.

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Area of Science:

  • Immunogenetics
  • Genomics
  • Bioinformatics

Background:

  • The human leukocyte antigen (HLA) complex, located on chromosome 6p21.3, contains over 220 genes, many involved in immune function.
  • Highly polymorphic HLA genes significantly impact clinical transplantation outcomes and susceptibility to non-infectious diseases.

Purpose of the Study:

  • To detail the IMGT/HLA database, a specialized resource for human leukocyte antigen (HLA) gene sequences.
  • To highlight the database's utility for retrieving, analyzing, and submitting HLA allele data.

Main Methods:

  • Curated sequence data from EMBL/GenBank/DDBJ databases.
  • Inclusion of all WHO-recognized HLA alleles.
  • Development of online tools for data retrieval, analysis, and submission.

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Main Results:

  • The IMGT/HLA database (release 1.10.0) contains 1329 HLA alleles and 61 related sequences.
  • Provides access to allele reports, alignment tools, and source cell descriptions.
  • Facilitates direct submission of new and confirmatory HLA sequences to the WHO Nomenclature Committee.

Conclusions:

  • The IMGT/HLA database serves as a vital, centralized resource for HLA genetic information.
  • The database model is extensible for creating specialized databases for other species' MHC genes.