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Updated: Jul 31, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
The IMGT/HLA sequence database
1Anthony Nolan Research Institute, London, UK.
Reviews in Immunogenetics
|October 4, 2002
Summary
The IMGT/HLA database provides a comprehensive resource for human leukocyte antigen (HLA) gene sequences, crucial for understanding transplantation and disease susceptibility. It offers tools for analysis and submission of new HLA allele data.
Area of Science:
- Immunogenetics
- Genomics
- Bioinformatics
Background:
- The human leukocyte antigen (HLA) complex, located on chromosome 6p21.3, contains over 220 genes, many involved in immune function.
- Highly polymorphic HLA genes significantly impact clinical transplantation outcomes and susceptibility to non-infectious diseases.
Purpose of the Study:
- To detail the IMGT/HLA database, a specialized resource for human leukocyte antigen (HLA) gene sequences.
- To highlight the database's utility for retrieving, analyzing, and submitting HLA allele data.
Main Methods:
- Curated sequence data from EMBL/GenBank/DDBJ databases.
- Inclusion of all WHO-recognized HLA alleles.
- Development of online tools for data retrieval, analysis, and submission.
Main Results:
- The IMGT/HLA database (release 1.10.0) contains 1329 HLA alleles and 61 related sequences.
- Provides access to allele reports, alignment tools, and source cell descriptions.
- Facilitates direct submission of new and confirmatory HLA sequences to the WHO Nomenclature Committee.
Conclusions:
- The IMGT/HLA database serves as a vital, centralized resource for HLA genetic information.
- The database model is extensible for creating specialized databases for other species' MHC genes.
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