Related Experiment Video
Updated: Jul 20, 2026
06:29
Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
Published on: March 18, 2016
Believe it or not--silver still poisons!
1Washington Poison Center, Seattle 98125-8012, USA.
Veterinary and Human Toxicology
|October 4, 2002
Summary
Naturopathic hydrolyzed silver treatments can cause argyria, a permanent skin discoloration. This condition, characterized by grayish skin, is linked to alternative medicine use and may worsen with sun exposure.
Area of Science:
- Dermatology
- Toxicology
- Alternative Medicine
Background:
- Silver compounds have historical therapeutic uses, including as a hemostatic agent for superficial bleeding.
- Modern alternative medicine practices incorporate silver, such as hydrolyzed silver, for purported health benefits.
Observation:
- Five cases of argyria (skin discoloration) were observed within a short period.
- Affected individuals included a couple with prolonged exposure to hydrolyzed silver and others using herbal remedies containing silver.
- The skin's grayish discoloration, exacerbated by sunlight, was a prominent symptom.
Findings:
- Naturopathic hydrolyzed silver treatment and herbal medications containing silver were identified as the likely causes of argyria.
- The condition resulted in persistent bluish or grayish discoloration of the skin, particularly on the face and hands.
- The increasing popularity of alternative medicine for conditions like anthrax prophylaxis may lead to more argyria cases.
Implications:
- Argyria is a significant adverse effect of ingesting or using silver-containing alternative therapies.
- Healthcare providers should be aware of the risks associated with alternative medicine and counsel patients accordingly.
- The permanent nature of skin discoloration necessitates careful consideration of silver-based treatments.
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