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Updated: Aug 17, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
Dietary cholesterol and coronary heart disease
William E Connor1, Sonja L Connor
1Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L465, Portland, OR 97239-3098, USA. connorw@ohsu.edu
Abstract:
Dietary cholesterol has been known as a dominant factor in the genesis of atherosclerosis since 1908. The evidence for the role of dietary cholesterol is based upon animal experiments, the chemistry of atherosclerotic plaques, worldwide epidemiology, and human feeding studies. All lines of evidence converge to indicate that dietary cholesterol is a major factor in promoting the growth of the atherosclerotic plaque by increasing its cholesterol content. Confusion about dietary cholesterol has arisen because amounts above a certain quantity (the ceiling) do not elevate plasma cholesterol and low-density lipoprotein cholesterol. The therapeutic threshold for dietary cholesterol is below 100 mg/d.
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