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ER quality control: a function for sugars in the cytosol
J Michael Lord1, Lorenzo Frigerio
1Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK.
Current Biology : CB
|October 4, 2002
Abstract:
Misfolded glycoproteins in the endoplasmic reticulum of a eukaryotic cell are exported to the cytosol, where they are proteolytically degraded by the ubiquitin-proteasome system. A recent study has identified a novel E3 ubiquitin ligase that recognises target glycoproteins via their sugar moieties.