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Updated: Sep 29, 2026
08:32
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
A battle for survival: immune control and immune evasion in murine gamma-herpesvirus-68 infection
Philip G Stevenson1, Jessica M Boname, Brigitte de Lima
1Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP, Cambridge, UK. pgs27@mole.bio.cam.ac.uk
Microbes and Infection
|October 4, 2002
Abstract:
CD8(+) T cells are generally considered a key defence against herpesviruses. The murine gamma-herpesvirus-68 encodes two proteins that limit their efficacy. M3 neutralizes chemokines, while K3 downregulates MHC class I glycoproteins. The consequence of this evasion is that CD4(+) T cells are essential to the control of persistent infection.
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