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Related Experiment Videos

Functional proteomics: The goalposts are moving.

Michael J Hubbard1

  • 1Department of Biochemistry, University of Otago, Dunedin, New Zealand. mike.hubbard@stonebow.otago.ac.nz

Proteomics
|October 4, 2002
PubMed
Summary
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Proteomics provides deeper protein function insights beyond genomics. New methods enhance proteomic analysis, crucial for understanding proteins with unknown roles, like ERp29.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genomics
  • Proteomics

Background:

  • The post-genome era prioritizes understanding protein function.
  • Genomic approaches offer insights but are limited at the protein level.
  • Proteomics provides physiologically relevant data on protein function.

Purpose of the Study:

  • To highlight the evolving role of proteomics in determining protein function.
  • To discuss the challenges and advancements in proteomic analysis.
  • To examine the case of ERp29, an endoplasmic reticulum protein, as an example.

Main Methods:

  • Review of functional genomic and proteomic approaches.
  • Analysis of recent advancements in proteomic technologies.

Related Experiment Videos

  • Case study of ERp29 function elucidation.

    • Main Results:

    • Proteomics offers richer functional data compared to genomics alone.
    • Advances enable deeper and more efficient proteome analyses.
    • The function of novel proteins, such as ERp29, can remain challenging to determine.

    Conclusions:

    • Proteomics is a powerful tool for protein function discovery.
    • There is increasing demand for high-value functional information from proteomics.
    • Future proteomics efforts must integrate with other methods to fully elucidate protein roles.