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Related Experiment Videos

G-protein-coupled receptor microarrays.

Ye Fang1, Anthony G Frutos, Joydeep Lahiri

  • 1Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, NY 14831, USA.

Chembiochem : a European Journal of Chemical Biology
|October 4, 2002
PubMed
Summary
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Researchers created microarrays of G-protein-coupled receptors (GPCRs), crucial drug targets, using robotic printing. This enables efficient screening of potential drug ligands on these membrane-bound proteins.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Membrane-bound proteins are vital drug targets.
  • Maintaining protein conformation in vitro is challenging for membrane proteins.

Purpose of the Study:

  • To develop a method for arraying membrane-bound proteins.
  • To enable ligand screening using G-protein-coupled receptor (GPCR) microarrays.

Main Methods:

  • Fabrication of protein microarrays using robotic pin-printing.
  • Embedding G-protein-coupled receptors (GPCRs) in membranes on slides.

Main Results:

  • Successfully created microarrays of GPCRs.
  • Demonstrated assays for ligand screening on these arrays.

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Conclusions:

  • Robotic printing enables GPCR microarray fabrication.
  • Developed platform facilitates drug discovery by enabling ligand screening.