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Related Experiment Videos

Inflammatory processes in amyotrophic lateral sclerosis.

P L McGeer1, E G McGeer

  • 1Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Muscle & Nerve
|October 4, 2002
PubMed
Summary

Neuroinflammation, marked by activated immune cells and elevated cyclooxygenase 2 (COX-2), is present in amyotrophic lateral sclerosis (ALS). Targeting COX-2 may offer a therapeutic strategy for ALS treatment.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Neuroinflammation is a key feature in neurodegenerative disorders.
  • Amyotrophic lateral sclerosis (ALS) exhibits neuroinflammatory changes in the brainstem and spinal cord.

Purpose of the Study:

  • To investigate the cellular and biochemical characteristics of neuroinflammation in ALS.
  • To identify potential therapeutic targets for ALS treatment.

Main Methods:

  • Histopathological examination of affected tissues from ALS cases and mouse models.
  • Analysis of biochemical markers associated with inflammation and oxidative stress.

Main Results:

  • Accumulation of activated microglia and astrocytes, with T cell infiltration, observed in ALS spinal cord.

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  • Evidence of free-radical damage, complement cascade activation, and significant upregulation of cyclooxygenase 2 (COX-2).

    • Conclusions:

    • Neuroinflammation, particularly COX-2 upregulation, is a prominent feature in ALS.
    • COX-2 presents an attractive therapeutic target for managing ALS progression.