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Updated: Aug 16, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
[Meningitis caused by herpes simplex virus type 2]
1Infektionsmedicinsk afdeling Q, Skejby Sygehus, Braendstrupgårdsvej 100, DK-8240 Arhus N. lohse@dadlnet.dk
Abstract:
Herpes simplex virus type 1 (HSV-1) is well-known as a cause of orolabial ulcers, whereas HSV-2 predominantly causes genital infections. Furthermore, HSV can lead to severe infections in the central nervous system (CNS). In adults, HSV encephalitis is predominantly caused by HSV-1, whereas HSV-2 mainly leads to aseptic meningitis, the symptoms of which are seen with or without concurrent genital ulcers. We describe four cases of HSV-2-associated aseptic meningitis. One of the patients had a primary HSV infection, and another had recurrent aseptic meningitis. All the patients recovered without neurological sequelae.
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