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Calcium-induced long-term potentiation in horizontal connections of rat motor cortex
1Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060, Krakow, Poland. hess@zuk.iz.uj.edu.pl
Brain Research
|October 5, 2002
Abstract:
A transient (10 min) exposure of brain slices of young adult rats to elevated extracellular calcium (5 mM) resulted in a long-lasting potentiation of field potentials evoked in layer II/III and layer V horizontal connections of the primary motor cortex. This form of synaptic plasticity was blocked by D,L-2-amino-5-phosphonovalerate (APV, 100 micro M), an antagonist of NMDA receptors.