Related Experiment Videos
Two different karyotypes with 1q abnormalities in a patient with Fanconi anemia
Neide I S S Oliveira1, Enilze M S F Ribeiro, Susana C Raimondi
1Laboratório de Citogenética Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Caixa Postal 19071, CEP 81531-970, Curitiba, Paraná, Brazil
Leukemia Research
|October 5, 2002
Abstract:
We report a case of Fanconi anemia in which cytogenetic analysis of bone marrow (BM) samples revealed two distinct karyotypes: 46,XY,dup(1)(q21q42), in the first sample and 46,XY,del(1)(q32) in the second, aspirated 7 months later after acute myeloid leukemia (AML) developed. We discuss the cytogenetic clonal fluctuation common in Fanconi anemia, with the Fanconi's anemia (FA) reports available in the literature. Interestingly, we have identified that del(1)(q32) has not been reported before in FA.