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Related Experiment Videos

Elevated regional lipolysis in hyperthyroidism.

Anne Lene Dalkjaer Riis1, Claus Højbjerg Gravholt, Christian Born Djurhuus

  • 1Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital and Institute of Experimental Clinical Science, Aarhus University, Aarhus 8000, Denmark. anne.lene.riis@iekf.au.dk

The Journal of Clinical Endocrinology and Metabolism
|October 5, 2002
PubMed
Summary
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Hyperthyroidism increases lipolysis in both abdominal and femoral fat depots. Both fat tissues become resistant to insulin

Area of Science:

  • Endocrinology
  • Metabolism
  • Adipose Tissue Biology

Background:

  • Hyperthyroidism is associated with elevated free fatty acids (FFA) and lipid oxidation.
  • The specific contribution of different fat depots to increased lipolysis in hyperthyroidism remains unclear.

Purpose of the Study:

  • To determine the role of abdominal and femoral adipose tissue in lipolysis during hyperthyroidism.
  • To investigate the impact of insulin on lipolysis in these fat depots in hyperthyroid individuals.

Main Methods:

  • Studied nine women with newly diagnosed hyperthyroidism (HT) and after treatment (euthyroidism, ET), compared to eight controls (CTR).
  • Utilized microdialysis in abdominal and femoral adipose tissue during a 3-hour hyperinsulinemic euglycemic clamp.
  • Measured interstitial glycerol concentrations as an indicator of lipolysis.

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Main Results:

  • Basal lipolysis, indicated by interstitial glycerol, was elevated in both abdominal and femoral fat in hyperthyroid patients compared to euthyroid and control groups.
  • These elevated lipolysis rates persisted even during the hyperinsulinemic clamp, suggesting insulin resistance in adipose tissue.
  • Femoral and abdominal adipose tissue contributed equally to the increased lipolysis observed in hyperthyroidism.

Conclusions:

  • Both abdominal and femoral adipose tissue significantly contribute to excessive lipolysis in hyperthyroidism.
  • Adipose tissue in hyperthyroid individuals exhibits resistance to the lipolytic actions of insulin.