Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastrointestinal dysfunction in amyotrophic lateral sclerosis.

M Toepfer1, C Folwaczny, A Klauser

  • 1Friedrich-Baur-Institut Ludwig-Maximilians-Universität Ziemssenstr. 1 80336 Munich, Germany. toepfer@fbs.med.uni-muenchen.de

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
|October 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Qualitative and quantitative muscle ultrasound in patients with Duchenne muscular dystrophy: Where do sonographic changes begin?

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2020
Same author

Rare intronic mutation between Exon 62 and 63 (c.9225-285A>G) of the dystrophin gene associated with atypical BMD phenotype.

Neuromuscular disorders : NMD·2020
Same author

Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2020
Same author

Novel SBF2 mutations and clinical spectrum of Charcot-Marie-Tooth neuropathy type 4B2.

Clinical genetics·2018
Same author

Early-Onset Myopathies: Clinical Findings, Prevalence of Subgroups and Diagnostic Approach in a Single Neuromuscular Referral Center in Germany.

Journal of neuromuscular diseases·2017
Same author

[Spinal muscular atrophy : Time for newborn screening?]

Der Nervenarzt·2017

Amyotrophic lateral sclerosis (ALS) can affect gastrointestinal function, even without noticeable symptoms. Studies reveal delayed gastric emptying and colonic transit in ALS patients, indicating subclinical autonomic system involvement.

Area of Science:

  • Neurology
  • Gastroenterology
  • Autonomic Neuroscience

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily affecting motor neurons.
  • Emerging evidence indicates ALS involves non-motor systems, including the autonomic nervous system.
  • Subclinical autonomic dysfunction, affecting functions like heart rate and sweating, is documented in ALS.

Purpose of the Study:

  • To investigate gastrointestinal motor function in patients with amyotrophic lateral sclerosis.
  • To assess for subclinical gastrointestinal abnormalities using non-invasive techniques.

Main Methods:

  • Utilized novel non-invasive techniques to evaluate gastrointestinal motility.
  • Assessed gastric emptying and colonic transit times in individuals with ALS.

Related Experiment Videos

Main Results:

  • Patients with amyotrophic lateral sclerosis exhibited delayed gastric emptying.
  • Delayed colonic transit times were observed in the ALS cohort.
  • These gastrointestinal dysfunctions occurred irrespective of patient-reported symptoms.

Conclusions:

  • Gastrointestinal motor dysfunction is a common, often subclinical, feature of amyotrophic lateral sclerosis.
  • Non-invasive evaluations highlight significant delays in gastric and colonic transit in ALS patients.
  • Findings underscore the widespread impact of ALS beyond motor neuron degeneration.