Related Experiment Videos
Emperipolesis in a common breast malignancy. A case report
Sunita Saxena1, K R Beena, Anju Bansal
1Institute of Pathology, Safdarjang Hospital Campus, New Delhi, India.
Acta Cytologica
|October 9, 2002
Summary
Emperipolesis, lymphocytes within cancer cells, was observed in breast cancer. This phenomenon correlated with a significant response to neoadjuvant chemotherapy, suggesting a tumoricidal effect.
Area of Science:
- Oncology
- Cell Biology
- Pathology
Background:
- Emperipolesis is defined as leukocytes or lymphocytes residing within the cytoplasm of other cells.
- This phenomenon is rarely observed in epithelial cancer cells, particularly in breast cancer.
Observation:
- A case study involving a 52-year-old female with breast cancer revealed emperipolesis within tumor cells.
- Histopathological examination confirmed infiltrating duct carcinoma with emperipolesis as a prominent feature.
Findings:
- The breast cancer exhibited a near-total response to neoadjuvant chemotherapy.
- Emperipolesis was a striking characteristic of the tumor cells in this case.
Implications:
- The presence of emperipolesis may indicate a role in achieving a tumoricidal effect.
- This phenomenon could be linked to chemokine-mediated immune responses contributing to chemotherapy efficacy.