1Institut für Anthropologie, Johannes Gutenberg-Universität Mainz, Colonel-Kleinmann-Weg 2, SB II-02, Mainz, Germany. meyec012@students.uni-mainz.de
The origin of syphilis is re-evaluated, suggesting non-venereal treponemal disease worldwide since Homo emergence. Venereal syphilis likely first appeared in 15th-century Europe, challenging the Columbian theory.
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