Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sentinel node detection in breast carcinoma.

E Pelosi1, V Arena, B Baudino

  • 1Servizio de Medicina Nucleare Universitario, Ospedale S Giovanni Battista, Turin, Italy. etpelosi@virgilio.itit

Tumori
|October 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Management of Burn Sequelae of the Popliteal Fossa: Retrospective Analysis and Development of a Management Algorithm.

Annals of burns and fire disasters·2026
Same author

Feasibility and impact of sentinel lymph node biopsy in patients affected by ano-rectal melanoma.

Techniques in coloproctology·2025
Same author

Short bowel disease after emergency surgery for massive intestinal infarction. A case report and review of the literature.

Annali italiani di chirurgia·2022
Same author

Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria.

BMC pregnancy and childbirth·2022
Same author

The gut microbiome as possible mediator of the beneficial effects of very low calorie ketogenic diet on type 2 diabetes and obesity: a narrative review.

Eating and weight disorders : EWD·2022
Same author

Risk of sudden cardiac death in a case of spontaneous coronary artery dissection presenting with thyroid storm.

European review for medical and pharmacological sciences·2022
Same journal

End-of-life decisions and opinions: Results of E.L.D.Y.-CA.RE study carried out at Veneto Institute of Oncology, Italy.

Tumori·2026
Same journal

Quality indicators in identification and care of patients with genetic predisposition to cancer: An AIFET proposal.

Tumori·2026
Same journal

Driver vs. passenger: Primary resistance to larotrectinib in synovial sarcoma harboring concurrent SS18 rearrangement and PDE3A-NTRK2 fusion.

Tumori·2026
Same journal

Beyond the calendar: A narrative review on chronobiological drivers of prognosis in resectable NSCLC.

Tumori·2026
Same journal

Challenging the cornerstone: Toward risk-adapted follow-up in early breast cancer.

Tumori·2026
Same journal

Assessing in house comprehensive genomic profiling by liquid biopsy for NSCLC patients.

Tumori·2026
See all related articles

Sentinel lymph node (SLN) biopsy accurately stages breast cancer axillary nodes, reducing unnecessary dissections. This method identifies metastatic disease in 21% of patients, sparing others from morbidity.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Imaging

Background:

  • Complete lymph node dissection is standard for breast cancer axillary staging but causes morbidity.
  • Approximately 70% of patients have no axillary metastatic disease, making dissection unnecessary.
  • Sentinel lymph node (SLN) biopsy offers a less invasive alternative for axillary staging.

Purpose of the Study:

  • To evaluate the accuracy and efficacy of SLN biopsy in staging axillary nodal involvement in breast cancer patients.
  • To determine the rate of SLN metastasis and its correlation with overall axillary nodal status.
  • To assess the potential of SLN biopsy to reduce the need for complete axillary dissection.

Main Methods:

  • A prospective study of 201 breast cancer patients (excluding specific criteria) over 18 months.

Related Experiment Videos

  • 99mTc-labeled colloid and vital blue dye were used for SLN identification prior to surgery.
  • SLNs were examined histologically, with axillary dissection performed only for positive SLNs.

    • Main Results:

    • SLNs were localized in 96.5% of patients; 100% success with combined techniques.
    • SLN metastases were found in 21% of patients (7.8% micrometastases).
    • Of patients with SLN metastases, 68% had involvement in other axillary nodes; no negative SLN patients developed metastases during follow-up.

    Conclusions:

    • SLN biopsy is an accurate method for axillary staging in breast cancer.
    • While not definitively correlated with negative axillary status, SLN biopsy significantly reduces unnecessary complete lymph node dissections.
    • This technique improves patient outcomes by minimizing surgical morbidity associated with axillary dissection.