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Related Experiment Videos

Sentinel node detection with imaging probe.

O Schillaci1, G D'Errico, R Scafè

  • 1Tor Vergata University, Rome, Italy.

Tumori
|October 9, 2002
PubMed
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The imaging probe (IP), a mini gamma camera, effectively detected sentinel lymph nodes (SLNs) in breast cancer patients. IP demonstrated comparable or superior performance to the Neoprobe 2000 in localization speed and operator confidence.

Area of Science:

  • Nuclear Medicine
  • Surgical Oncology
  • Medical Imaging

Background:

  • The imaging probe (IP) is a mini gamma camera developed for sentinel lymph node (SLN) detection.
  • Previous use focused on initial SLN detection, with ongoing research in radioguided orthopedic surgery.

Purpose of the Study:

  • To evaluate the IP's utility for SLN localization in breast cancer patients by a trained medical team in a clinical setting.
  • To gain experience for future surgical applications and initiate multicenter trials.

Main Methods:

  • Six breast cancer patients undergoing lymphoscintigraphy for SLN biopsy were included.
  • SLN identification and localization were performed using the IP and a non-imaging probe (Neoprobe 2000).
  • Operators were blinded to findings from other devices, including a large-field-of-view Anger camera.

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Main Results:

  • Seven SLNs were detected across six patients by the Anger camera, IP, and Neoprobe.
  • Mean detection time was 2 minutes 6 seconds (SD 26s) for IP and 2 minutes 18 seconds (SD 47s) for Neoprobe 2000.
  • Operator confidence was "absolutely sure" for 7/7 SLNs with IP versus 5/7 with Neoprobe.

Conclusions:

  • The imaging probe (IP) is effective for sentinel lymph node localization in breast cancer patients.
  • IP offers comparable or faster detection times and higher operator confidence compared to the Neoprobe 2000.
  • The findings support further multicenter trials and broader clinical application of the IP.