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A randomized, double-masked clinical trial of Optisol-GS vs Chen Medium for human corneal storage
Joel Naor1, Allan R Slomovic, Mary Chipman
1Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada. joelnaor@hotmail.com
Objective:
To determine whether the clinical outcome of corneal transplantation performed with tissue stored in Chen Medium (CM; Chen Laboratories, Phoenix, Md) is superior to that of Optisol-GS (Chiron Ophthalmics, Irvine, Calif).
Design:
Randomized, double-masked trial.
Participants And Setting:
Ninety patients undergoing corneal transplantation at a tertiary center.
Intervention:
Donor cornea pairs were stored, one in CM and the other in Optisol-GS, transplanted, and followed up for 3 months.
Main Outcome Measures:
Endothelial cell loss (ECL) at 3 months. Secondary outcomes were thickness and epithelialization at days 1, 7, 30, and 90, as well as primary and secondary graft failure.
Results:
Mean percentages of ECL 3 months after surgery were similar for corneas stored in Optisol-GS and corneas stored in CM. The 95% confidence interval (CI) for the difference was -3.4% to 13.2%. Covariate-adjusted 95% CI was -6.1% to 9.1%. Pachymetry values were similar in the 2 treatment groups. Eighty-eight percent of the corneas stored in each medium achieved epithelialization of 75% to 100% of the surface area within 1 week after transplantation. No primary donor failures occurred in either group. One graft that was preserved in CM failed during the study period.
Conclusion:
The clinical outcomes of corneal transplantation with tissue that was preserved in CM were similar to those of grafts preserved in Optisol-GS.