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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

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Proteomics in cancer research.

W Wu¹, W Hu, J J Kavanagh

¹Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA. weiguowu@manderson.org

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society

|October 9, 2002

Summary

Proteomics, the study of proteins, is advancing cancer research beyond genomics. It offers new ways to detect cancer early, develop targeted therapies, and monitor treatment effectiveness.

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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

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Area of Science:

Molecular Medicine
Proteomics
Cancer Research

Background:

The human genome sequence is complete, shifting focus to proteomics in molecular medicine.
Cancer research is exploring how proteomics can be applied in both basic science and clinical settings.

Purpose of the Study:

To review key themes in proteomics relevant to clinical cancer research.
To explore the application of proteomics in discovering biomarkers, drug targets, and therapeutic assessment.

Main Methods:

Review of current literature on proteomics in cancer research.
Analysis of proteomics applications in early detection, diagnosis, drug development, and treatment monitoring.

Main Results:

Proteomics enables the discovery of novel biomarkers and tumor markers.
Identifies new protein-based targets for anticancer drug development.
Provides new endpoints for evaluating treatment efficacy and toxicity.

Conclusions:

Proteomics is crucial for advancing cancer research in the postgenomic era.
Applications range from diagnostics to novel therapeutic strategies and outcome assessments.