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HLA B27 polymorphism in Western India.

U Shankarkumar1, K Ghosh, D Mohanty

  • 1HLA Department, Institute of Immunohaematology (ICMR), KEM, Hospital Parel, Mumbia, India.Shankarkumar16@hotmail.com

Tissue Antigens
|October 9, 2002
PubMed
Summary

This study identified specific Human Leukocyte Antigen B27 (HLA B27) subtypes in Western Indian individuals. Novel alleles B*2708 and B*2714 were discovered, with B*2714 linked to ankylosing spondylitis.

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Area of Science:

  • Immunogenetics
  • Molecular Anthropology

Background:

  • Human Leukocyte Antigen B27 (HLA B27) is strongly associated with various inflammatory diseases, particularly ankylosing spondylitis.
  • Understanding HLA B27 allele distribution is crucial for disease association studies and population genetics.

Purpose of the Study:

  • To characterize the spectrum of HLA B27 alleles in a Western Indian population from Maharashtra.
  • To identify novel HLA B27 subtypes within this ethnic group.

Main Methods:

  • Polymerase chain reaction with sequence-specific primers (PCR-SSP) was employed for HLA B27 allele typing.
  • Reverse line strip (RLS) technique was utilized to confirm and further characterize the identified alleles.

Main Results:

  • The study identified HLA B27 alleles B*2704, B*2705, B*2707, B*2708, and B*2714 in the Maharastra population.
  • Two previously undescribed HLA B27 alleles, B*2708 and B*2714, were identified in this Indian cohort.
  • The novel allele B*2714 was detected in a patient diagnosed with ankylosing spondylitis, representing a new association in this ethnic group.

Conclusions:

  • This research expands the known diversity of HLA B27 alleles in Indian populations.
  • The discovery of novel alleles and their potential association with ankylosing spondylitis warrants further investigation.
  • These findings contribute to the understanding of HLA B27's role in autoimmunity within diverse ethnic contexts.

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