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Initial effect of controlled release chlorhexidine on subgingival microorganisms.
Nazanin Daneshmand1, Michael G Jorgensen, Hessam Nowzari
1Department of Periodontology, Division of Biostatistics, University of Southern California, Los Angeles, CA, USA.
Journal of Periodontal Research
|October 9, 2002
Summary
Adding the chlorhexidine chip to scaling and root planing (Sc/Rp) provided no significant antimicrobial benefit for periodontitis. Thorough Sc/Rp alone was as effective in reducing periodontopathic microorganisms.
Area of Science:
- Periodontology
- Microbiology
- Dental Therapeutics
Background:
- Limited data exist on subgingival PerioChip (chlorhexidine gluconate) efficacy against periodontopathic microorganisms.
- This study compared subgingival microbiota following chlorhexidine chip plus scaling and root planing (Sc/Rp) versus Sc/Rp alone.
Purpose of the Study:
- To evaluate the antimicrobial effects of subgingival chlorhexidine chip application in conjunction with scaling and root planing (Sc/Rp) for periodontitis treatment.
- To compare the subgingival microbial profile of periodontitis sites treated with the chlorhexidine chip plus Sc/Rp versus Sc/Rp alone.
Main Methods:
- 13 adult patients with moderate to advanced periodontitis participated.
- Bilateral periodontal pockets were treated with either chlorhexidine chip + Sc/Rp or Sc/Rp alone.
- Subgingival samples were collected at baseline, 2, and 4 weeks post-treatment for anaerobic culture and identification.
Main Results:
- No statistically significant difference in total bacterial colony counts was observed between the two treatment groups.
- The percentage of major and total periodontal pathogens did not differ significantly between the chlorhexidine chip + Sc/Rp and Sc/Rp alone groups.
- While some pathogens decreased in the chlorhexidine chip group by 4 weeks, the differences were not statistically significant compared to Sc/Rp alone.
Conclusions:
- Subgingival chlorhexidine chip treatment offers minimal to no additional antimicrobial benefit compared to thorough scaling and root planing (Sc/Rp) alone for adult periodontitis lesions.
- The findings suggest that effective mechanical debridement (Sc/Rp) is the primary driver of microbial reduction in this context.
- Further research may be warranted to identify specific patient populations or conditions where adjunctive chlorhexidine chip therapy demonstrates enhanced efficacy.