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Encephalomyelitis due to human parechovirus type 1.
Vincent Legay1, Jean Jacques Chomel, Eustace Fernandez
1Centre National de Reference pour les Enterovirus et L'hepatite A Laboratoire de Virologie, Domaine Rockefeller, Lyon, France.
Summary
Human parechovirus type 1 (HPEV1) was identified in a child with encephalomyelitis, marking the first such case. This finding highlights HPEV1 as a potential cause of severe central nervous system infections in pediatric patients.
Area of Science:
- Virology
- Pediatric Neurology
- Infectious Diseases
Background:
- Viral infections are implicated in encephalomyelitis.
- Human parechoviruses (HPVs) are an emerging cause of human illness.
Observation:
- A 10-month-old boy presented with encephalomyelitis.
- Clinical samples included throat and rectal swabs, sera, and cerebrospinal fluid.
Findings:
- Human parechovirus type 1 (HPEV1) was isolated from the patient's throat swab.
- HPEV1 genome was detected in cerebrospinal fluid, throat swab, and acute serum.
- Samples tested negative for cytomegalovirus, varicella zoster virus, mumps virus, and enteroviruses.
Implications:
- This is the first reported case linking HPEV1 to encephalomyelitis.
- HPVs should be considered in the differential diagnosis of pediatric central nervous system infections.
- Further research is needed to understand the pathogenesis of HPEV1-associated neurological disease.