Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Flow injection biamperometric determination of captopril.

Miriam E Palomeque¹, Beatriz S Fernández Band

¹Department of Chemistry and Eng Chemistry, FIA Laboratory, Universidad Nacional del Sur, Av Alem 1253, 8000 Bahía Blanca, Argentine.

Journal of Pharmaceutical and Biomedical Analysis

|October 9, 2002

Summary

An automated flow injection method accurately determines captopril using indirect biamperometric detection. This efficient technique is suitable for analyzing captopril in pharmaceutical preparations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatiotemporal distribution and human health risk assessment of potential toxic species in soils of urban and surrounding crop fields from an agricultural area, Córdoba, Argentina.

Environmental monitoring and assessment·2021

Same author

Fast Determination of Biodiesel Content in Commercial Diesel/Biodiesel Blends by Using Digital Images and Multivariate Calibration.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2017

Same author

Single excitation-emission fluorescence spectrum (EEF) for determination of cetane improver in diesel fuel.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2015

Same author

Second order advantage applied to the spectrophotometric analysis of ciprofloxacin and dexamethasone in ophthalmic drops; automatic green method using on-line photodegradation.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2014

Same author

Application of a fully integrated photodegradation-detection flow-batch analysis system with an on-line preconcentration step for the determination of metsulfuron methyl in water samples.

Talanta·2014

Same author

Validation of a continuous flow method for the determination of soluble iron in atmospheric dust and volcanic ash.

Talanta·2014

Area of Science:

Analytical Chemistry
Electrochemistry

Background:

Captopril is an important pharmaceutical agent.
Accurate quantification of captopril is crucial for quality control.

Purpose of the Study:

To develop an automated method for captopril determination.
To validate the method for pharmaceutical analysis.

Main Methods:

Flow injection analysis (FIA) manifold.
Indirect biamperometric detection using Fe(III)/Fe(II) redox system.
Z-shaped flow-cell configuration.

Main Results:

Linear calibration curve from 0.03-3.6 microg ml(-1) captopril.
Low relative standard deviation of 0.97% at 0.76 microg ml(-1).

Related Experiment Videos

High sample throughput of 69 samples per hour.

Conclusions:

The developed method provides accurate and precise captopril quantification.
The automated FIA method is effective for analyzing captopril in pharmaceutical products.