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Updated: Sep 29, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus
Pascal Trempat1, Julie Tabiasco, Pascale Andre
1Department of Pathology and Inserm U563, Centre de Physiopathologie de Toulouse, Purpan, France.
Abstract:
We examined lymph nodes and tonsils from patients with infectious mononucleosis by combined detection of EBV-encoded RNA and a specific marker of natural killer (NK) cells, PEN5. A small number of Epstein-Barr virus (EBV) latently infected nonneoplastic NK cells were detected. Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection.
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