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Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex

Susanne Wirth1, Annelyse Vessaz, Claude Krummenacher

  • 1Institute of Microbiology, University of Lausanne, CH-1011 Lausanne, Switzerland. Susanne.Wirth-dulex@chuv.hospvd.ch

Journal of Virology
|October 9, 2002
PubMed

To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

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