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Related Experiment Videos

Thrombophilias and recurrent miscarriage.

Amy M Adelberg1, Jeffrey A Kuller

  • 1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider, Chapel Hill, NC 27599-7516, USA.

Obstetrical & Gynecological Survey
|October 9, 2002
PubMed
Summary
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Acquired thrombophilias are linked to recurrent pregnancy loss, but evidence for inherited thrombophilias is unclear. Inherited thrombophilias are not recommended for initial RPL evaluation.

Area of Science:

  • Reproductive Medicine
  • Hematology

Background:

  • Thrombophilias, both inherited and acquired, are implicated in recurrent pregnancy loss (RPL).
  • Advances in detecting thrombotic tendency-related genetic and protein abnormalities have improved.
  • Distinguishing the specific risk associated with each thrombophilia for RPL is crucial.

Purpose of the Study:

  • To review diagnostic methods and evidence linking thrombophilias to recurrent pregnancy loss.
  • To clarify the role of inherited thrombophilias in RPL.
  • To guide clinical evaluation and management of RPL.

Main Methods:

  • Review of diagnostic techniques for inherited and acquired thrombophilias.
  • Analysis of existing literature on the association between thrombophilias and recurrent pregnancy loss.

Related Experiment Videos

  • Evaluation of evidence supporting or refuting the link between specific thrombophilias and RPL.

    • Main Results:

    • Acquired thrombophilias, such as lupus anticoagulant and anticardiolipin antibodies, show a link to RPL.
    • Evidence for inherited thrombophilias (Factor V Leiden, Prothrombin G20210A, MTHFR C677T, Antithrombin, Protein C, Protein S deficiencies) and RPL is less conclusive.
    • Treatment modalities for thrombophilias in RPL, beyond general thrombotic event prevention, are understudied.

    Conclusions:

    • Current data suggests insufficient evidence to routinely include inherited thrombophilias in the initial RPL assessment.
    • Focusing on more common causes of recurrent miscarriage is recommended during RPL evaluation.
    • Further research is needed to clarify the role and management of inherited thrombophilias in RPL.