Related Experiment Video
Updated: Mar 16, 2026

Determination of Glucan Chain Length Distribution of Glycogen Using the Fluorophore-Assisted Carbohydrate Electrophoresis FACE Method
Published on: March 31, 2022
Acrylamide is formed in the Maillard reaction
Donald S Mottram1, Bronislaw L Wedzicha, Andrew T Dodson
1School of Food Biosciences, The University of Reading, Whiteknights, Reading RG6 6AP, UK. d.s.dottram@reading.ac.uk
Acrylamide, a probable human carcinogen, forms in cooked foods through the Maillard reaction. Asparagine, an amino acid in potatoes and cereals, is key to its formation during heating.
Area of Science:
- Food chemistry
- Toxicology
- Biochemistry
Background:
- Acrylamide is found in various heat-treated foods, raising health concerns due to its probable carcinogenic classification in humans.
- The formation of acrylamide during cooking is a significant area of research impacting food safety.
Purpose of the Study:
- To elucidate the mechanism of acrylamide generation in food during heat treatment.
- To identify key food components involved in acrylamide formation.
Main Methods:
- Investigated the Maillard reaction between amino acids and reducing sugars as a pathway for acrylamide synthesis.
- Focused on the role of specific amino acids, particularly asparagine, in acrylamide production.
Main Results:
- Confirmed that the Maillard reaction is a primary route for acrylamide generation in foods.
- Identified asparagine as a critical amino acid precursor for acrylamide formation.
- Demonstrated the link between asparagine content in foods like potatoes and cereals and acrylamide levels.
Conclusions:
- Asparagine plays a crucial role in acrylamide formation via the Maillard reaction during food processing.
- Understanding this pathway is vital for developing strategies to reduce acrylamide levels in cooked foods.
- This research provides insights into mitigating potential health risks associated with dietary acrylamide exposure.
More Related Videos
Related Concept Videos
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Aldehydes and Ketones with Alcohols: Hemiacetal Formation
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Aldehydes and Ketones with Amines: Imine Formation Mechanism
Imines are formed under mildly acidic conditions. A pH of 4.5 is ideal for the reaction.
If the pH is low or the solution is too acidic, the reaction slows down in the...

