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Published on: January 19, 2019
[Effectiveness of combined treatment in patient with advanced ovarian carcinoma]
Izabella Rzepka-Górska1, Anita Chudecka-Głaz, Maria Kośmider
1Katedry i Kliniki Ginekologii Operacyjnej i Onkologii Ginekologicznej Dorosłych i Dziewczat PAM w Szczecinie.
Objective:
The objectives of this study was to evaluate chemotherapy, GnRH analogues and radiotherapy as adjuvant treatment in advanced epithelial ovarian carcinoma.
Materials And Methods:
It was a retrospective analysis. 69 patients with stage III and IV epithelial ovarian carcinoma after maximal debulking surgery received adjuvant chemotherapy with cyclophosphamide and cisplatin or carboplatin (6-9 course). Additionally some of them were treated with radiotherapy or/and GnRH agonists. In relation to treatment patients were divided into 4 groups: I--received chemotherapy + GnRH agonist + radiotherapy, II--chemotherapy + GnRH agonist, III--chemotherapy + radiotherapy and IV--chemotherapy. Statistical analysis was based on nonparametric U-Mann-Whitney test. Survival analysis performed with Kaplan-Meyer method.
Results:
We found statistical differences in overall survival, 5-years survival and overall complete response rate between the group treated with only chemotherapy and groups the also received radiotherapy or/and GnRH analogues.
Conclusion:
Combination treatment in advanced epithelial ovarian cancer seems to be a reasonable way of therapeutic management. Radiotherapy and GnRH agonists with chemotherapy are effective consolidation therapy for stage III and IV ovarian cancer.
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