Studies of platinum complex inhibition of leucine aminopeptidase

The inhibition of swine kidney leucine aminopeptidase by N-alkyl-substituted etyhlenediamine liganded dihaloplatinum chelates has been investigated. The rate of this inhibition at 37 degrees is considerably less than that for the platinum tetra- and hexahalo complexes and also the ethylenediamine dihalo chelates. Only mixed inhibition was observed in these studies. For the time studies used here little if any inhibition occurred at room temperature. L-Methionine and L-Ala-L-Met did not reverse the platinum chelate inhibition nor did they prevent it.