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Imidazolidinones structurally-related to penicillins: synthesis, molecular modeling and biological evaluation
J Marchand-Brynaer1, J Lamotte-Brasseur, G Dive
1Université Catholique de Louvain, Chimie Organique de synthèse, Louvain-la-Neuve, Belgium.
Drug Metabolism and Drug Interactions
|January 1, 1994
Abstract:
Several bicyclic imidazolidinones structurally-related to penicillins have been prepared from penam precursors. The compounds were compared to benzylpenicillin as active reference, using the methods of theoretical chemistry. Structures 7 and 8, in which the acyl group of the side-chain was anchored, via a "one-atom spacer", at position N-7 of the imidazolidinone ring, appeared as good penicillin mimics. However, they were found devoid of significant antibacterial activity.