Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computational tools for protein modeling.

D Xu1, Y Xu, E C Uberbacher

  • 1Computational Biosciences Section Life Sciences, Division Oak Ridge National Laboratory, TN 37831-6480, USA. xud@ornl.gov

Current Protein & Peptide Science
|October 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

D-amino acids for the enhancement of a binary biocide cocktail consisting of THPS and EDDS against an SRB biofilm.

World journal of microbiology & biotechnology·2012
Same author

A synergistic D-tyrosine and tetrakis hydroxymethyl phosphonium sulfate biocide combination for the mitigation of an SRB biofilm.

World journal of microbiology & biotechnology·2012
Same author

A green triple biocide cocktail consisting of a biocide, EDDS and methanol for the mitigation of planktonic and sessile sulfate-reducing bacteria.

World journal of microbiology & biotechnology·2012
Same author

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice.

Allergy·2012
Same author

Search for scalar bottom quark pair production with the ATLAS detector in pp collisions at sqrt[s]=7  TeV.

Physical review letters·2012
Same author

Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway.

Leukemia·2012
Same journal

Therapeutic Peptides as Targeting Vectors and Smart Therapeutics: Emerging Trends and Future Perspectives.

Current protein & peptide science·2026
Same journal

Innovative Protein Nanostructures and Hybrid Systems for Enhanced Encapsulation and Controlled Delivery of Bioactive Agents.

Current protein & peptide science·2026
Same journal

Nanotherapeutic Interventions in Diabetic Wound Healing: Biomarker- Guided Mechanisms and Translational Prospects.

Current protein & peptide science·2026
Same journal

Recent developments in intein-mediated protein splicing and their applications in bioengineering.

Current protein & peptide science·2026
Same journal

Amyloids of Food Proteins: Balancing Benefits and Risks.

Current protein & peptide science·2026
Same journal

Phosphodiesterase-5 Inhibitors in Neurodegenerative Diseases: A Path to Cognitive Rescue.

Current protein & peptide science·2026
See all related articles

Protein modeling tools are crucial in peptide and protein sciences, aiding in structure prediction, function elucidation, and drug design. This review introduces key computational programs and online servers for protein modeling applications.

Area of Science:

  • Computational Biology
  • Structural Biology
  • Bioinformatics

Background:

  • Protein modeling is increasingly vital in peptide and protein sciences.
  • Advances in computational methods, technology, and data availability drive its importance.
  • Modeling predicts structure, function, mechanisms, and aids experimental and drug design.

Purpose of the Study:

  • To provide a comprehensive review of major protein modeling computer programs and online servers.
  • To cover key aspects of protein modeling, from sequence analysis to 3D structure prediction.
  • To discuss the strengths, limitations, challenges, and future trends in protein modeling tools.

Main Methods:

  • Review of computational tools for protein sequence comparison (alignment, classification, domain parsing).

Related Experiment Videos

  • Analysis of tools for sequence annotation (hydrophobic profiles, active sites, secondary structures).
  • Exploration of software for protein structure analysis (visualization, dynamics, electrostatics) and 3D structure prediction (homology modeling, threading, ab initio, docking).

    • Main Results:

    • Identified and categorized major computational tools and online servers for protein modeling.
    • Detailed the capabilities of tools across sequence comparison, annotation, structure analysis, and 3D prediction.
    • Provided insights into the expected performance, limitations, and applications of these tools.

    Conclusions:

    • Protein modeling computational tools are essential for advancing protein and peptide sciences.
    • Understanding the capabilities and limitations of these tools is crucial for effective application.
    • The field faces ongoing challenges but shows promising future trends in computational protein research.