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Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy
1Department of Pharmaceutical Chemistry, Westfälische Wilhelms-Universität Münster, Germany. jungm@uni-muenster.de
Mini Reviews in Medicinal Chemistry
|October 9, 2002
Abstract:
In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.