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Updated: Sep 10, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Antihypertensive drugs that act on Renin-Angiotensin System with emphasis in AT(1) antagonists
T Mavromoustakos1, V Apostolopoulos, J Matsoukas
1Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece. tmavro@eie.gr
Abstract:
Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT(1) receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.
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