Related Experiment Video
Updated: Aug 2, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials
1Department of Chemistry, University of Cape Town, Private Bag Rondebosch 7701, South Africa. tegan@psipsy.uct.ac.za
Abstract:
Recent publication have provided strong evidence that activity and cellular uptake of 4-aminoquinoline antimalarials depends on vacuolar haemoglobin degradation and that haematin is the drug target. Studies on haematin-quinoline interactions have provided insight into the structural requirements for these interactions and indications are that 4-aminoquinolines may act by inhibiting haemozoin formation. Structural requirements for this activity have also been reported recently and have led to construction of an empirical structure-function relationship for 4-aminoquinolines.
More Related Videos
Related Concept Videos
Structure of Amines
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Antihypertensive Drugs: Thiazide-Class Diuretics
Anthelminthic Agents
Antiprotozoal Agents

