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Updated: Sep 29, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
A synthetic strategy for ON-resin amino acid specific multiple fatty acid acylation of peptides
Avaronnan Harishchandran1, Bhattaram Pallavi, Ramakrishnan Nagaraj
1Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
Abstract:
Covalent modification with fatty acids is observed in several proteins that play crucial roles in cellular physiology. In this paper, a convenient method for the generation of multiple fatty acylated synthetic peptides is described. Peptides were synthesized using solid phase procedures with fluorenylmethoxycarbonyl a-amino protected amino acids. Acetamidomethyl protected cysteines were employed. The thiol protecting group was selectively deprotected and acylation was carried out on the resin-bound peptides. The strategy described in this report is applicable to any peptide sequence.
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