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Structure-activity relationship, conformation and pharmacology studies of morphiceptin analogues--selective mu-opioid
Anna Janecka1, Jakub Fichna, Marek Mirowski
1Department of Medicinal Chemistry, Medical University of Lodz, 90-131 Lodz, Poland. ajanecka@csk.am.lodz.pl
Mini Reviews in Medicinal Chemistry
|October 9, 2002
Abstract:
Morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) is one of the most selective agonists for the mu-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.