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Updated: Jan 4, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

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Mimetics of the peptide beta-strand.

Matthew P Glenn¹, David P Fairlie

¹Centre for Drug Design and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia.

Mini Reviews in Medicinal Chemistry

|October 9, 2002

Summary

Researchers are developing stable, bioavailable drug leads by mimicking peptide beta strands. This approach uses non-peptidic constraints to create molecules with drug-like properties and high receptor affinity.

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Area of Science:

Medicinal Chemistry
Drug Discovery
Chemical Biology

Background:

Peptides are valuable in drug discovery but have limitations like poor stability and bioavailability.
Non-peptidic constraints can replace amide bonds, imparting drug-like properties to peptide mimics.
Mimicking protein secondary structures, like beta strands, can enhance molecular recognition and binding affinity.

Purpose of the Study:

To summarize strategies for creating constrained peptide beta strand mimics.
To present examples of molecules that mimic extended peptide beta strands.
To highlight the potential of these mimics as stable and bioavailable drug leads.

Main Methods:

Reviewing and synthesizing existing literature on peptide beta strand mimetics.
Designing and synthesizing conformationally constrained molecules.
Evaluating the stability, bioavailability, and bioactivity of designed molecules.

Main Results:

Several approaches to constructing constrained beta strand mimics have been identified.
Examples of bioactive, stable, and bioavailable molecules mimicking peptide beta strands are presented.
Conformationally biased molecules demonstrate high affinity for target receptors.

Conclusions:

Constrained peptide beta strand mimetics offer a promising strategy for developing novel therapeutics.
Replacing amide bonds with non-peptidic constraints overcomes peptide limitations.
Engineered molecules preorganized into bioactive conformations can lead to highly effective drug candidates.