Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptidomimetics and peptide backbone modifications.

Jung-Mo Ahn1, Nicholas A Boyle, Mary T MacDonald

  • 1Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.

Mini Reviews in Medicinal Chemistry
|October 9, 2002
PubMed
Summary

Peptide mimicry uses amide bond replacements to create peptidomimetics. This review covers common surrogates and their biological uses, highlighting laboratory research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antioxidant and Neuroprotective Effects of 20% Marigold Extract Oil (Lutein/Zeaxanthin Complex) in LED-induced Retinal Injury and A2E-mediated ARPE-19 Models.

In vivo (Athens, Greece)·2026
Same author

Redefining Drug Immune Recognition: A Radically Reconfigured Molecular Architecture Enables Broad Fentanyl-Class Protection.

Journal of medicinal chemistry·2026
Same author

Targeting LIPA with ERX-41 Induces ER Stress and Inhibits Tumor Progression in Inflammatory Breast Cancer.

Biomolecules·2026
Same author

Fentanyl-Rewired: A 2‑Azaspiro[3.3]heptane Core Preserves μ‑Opioid Function.

ACS medicinal chemistry letters·2026
Same author

Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancer.

Oncogene·2026
Same author

Bifunctional Behavior of Conformationally Constrained Methamphetamine Analogs: Unexpected Heteroclitic Immune Response and Antagonist Effects Altering Methamphetamine and Fentanyl Pharmacology.

Journal of medicinal chemistry·2025

Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Biochemistry

Background:

  • The peptide backbone contains amide bonds crucial for protein structure and function.
  • Peptide mimicry involves replacing these amide bonds to create molecules with similar properties but enhanced stability or activity.
  • Developing effective amide bond surrogates is key to advancing peptide-based therapeutics.

Purpose of the Study:

  • To review common amide bond surrogates used in peptide mimicry.
  • To discuss the synthesis and properties of these peptidomimetics.
  • To highlight the biological applications and therapeutic potential of amide bond surrogates.

Main Methods:

  • Literature review of existing research on amide bond surrogates.
  • Analysis of synthetic strategies for creating peptidomimetics.

Related Experiment Videos

  • Examination of biological data and case studies demonstrating applications.

    • Main Results:

    • Identification and categorization of several prevalent amide bond surrogates.
    • Discussion of the advantages of specific surrogates over traditional amide bonds (e.g., resistance to enzymatic degradation).
    • Examples of successful applications in areas like drug discovery and materials science.

    Conclusions:

    • Amide bond surrogates are versatile tools in peptide mimicry.
    • These peptidomimetics offer significant advantages for biological applications.
    • Continued research into novel surrogates holds promise for future therapeutic development.