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Retrospective clinical comparison of Celsior solution to modified blood Wallwork solution in lung transplantation for
1Thoracic Transplantation Unit, Cardiovascular Surgery Department, Laennec Hospital, Nantes, France.
Objective:
To compare the preservative effects of Celsior solution and modified blood Wallwork solution in lung transplantation.
Methods:
From 1989 to 2000, 44 lung transplantations for cystic fibrosis were performed: 26 grafts were preserved with modified blood Wallwork solution and 18 with Celsior solution.
Results:
Preoperative status of the 2 groups was similar. The ratio of arterial oxygen to fraction of inspired oxygen and the pulmonary vascular resistance on the first postoperative day did not differ significantly between the 2 groups. Early death was 4% (SD, 20%) in the Wallwork group versus 11% (SD, 32%) in the Celsior group (not significant). No death was related to graft failure. The forced expiratory volume in 1 second during the first month after transplantation was 63% (SD, 19%) in the Wallwork group versus 63% (SD, 16%) in the Celsior group (not significant).
Conclusion:
Because the solution does not need to be prepared on site and does not require blood from the donor, Celsior seems better than Wallwork solution for preserving lung grafts.