Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sensory-motor gating and cognitive control by the brainstem cholinergic system.

Yasushi Kobayashi1, Tadashi Isa

  • 1Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.

Neural Networks : the Official Journal of the International Neural Network Society
|October 10, 2002
PubMed
Summary

The brainstem cholinergic system, particularly the pedunculopontine tegmental nucleus (PPTN), facilitates motor command generation and sensory processing. Further research is needed to understand its role in intrinsic brain processing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

Neurosurgery·2026
Same author

Enhanced sensorimotor cortex responsiveness to nonplegic hand stimulation and motor network assembly during recovery after spinal cord injury in primates.

Scientific reports·2026
Same author

Biological validation of mathematically derived hypothesis in neuroscience.

Current opinion in neurobiology·2026
Same author

Connectivity of the Superior Temporal Polysensory Area With the Presubiculum, Parasubiculum, Entorhinal Cortex, and Claustrum-Endopiriform Complex in the Common Marmoset (Callithrix jacchus).

The Journal of comparative neurology·2026
Same author

Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species.

PloS one·2026
Same author

Two cases with fenestrations in the left renal veins for the passages of the renal, gonadal, and suprarenal arteries.

Anatomy & cell biology·2026

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neurobiology

Background:

  • Cholinergic neurons are crucial for cognitive functions like attention and memory.
  • Existing models propose acetylcholine facilitates cortical input and inhibits intracortical processing.

Purpose of the Study:

  • To explore a generalized principle of cholinergic system function in the brain.
  • To summarize knowledge on the pedunculopontine tegmental nucleus (PPTN) actions in target regions.

Main Methods:

  • In vitro experiments on superior colliculus.
  • Electrophysiological recordings in behaving monkeys.
  • Review of existing literature on PPTN.

Main Results:

  • Cholinergic inputs from PPTN facilitate saccade initiation via superior colliculus.

Related Experiment Videos

  • Cholinergic inputs enhance dopaminergic cell responses to reward signals.
  • PPTN neurons exhibit multi-modal activity linked to movement, task performance, and reward.

    • Conclusions:

    • Brainstem cholinergic system, exemplified by PPTN, facilitates motor command generation and extrinsic sensory processing.
    • PPTN activity links movement, task engagement, and reward.
    • Further investigation is required to elucidate the brainstem cholinergic system's impact on intrinsic brain processing.