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Impact of renal failure on the risk of myocardial infarction and death

Srinivasan Beddhu1, Kristina Allen-Brady, Alfred K Cheung

  • 1Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA. Srinivasan.beddhu@hsc.utah.edu

Kidney International
|October 10, 2002
PubMed

Insights

Renal failure significantly increases the risk of myocardial infarction and death, even at moderate stages. This risk is independent of other known cardiovascular disease factors and treatments.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • High cardiovascular morbidity and mortality are observed in patients with renal failure.
  • It remains unclear if pre-existing cardiovascular disease or the uremic state itself drives this increased risk.

Purpose of the Study:

  • To determine if renal failure independently elevates the risk of myocardial infarction and death.

Main Methods:

  • The Intermountain Heart Study included 8600 patients undergoing coronary angiography.
  • Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease formula.
  • Cox regression models analyzed the association between GFR and outcomes like myocardial infarction and death.

Main Results:

  • Patients in the lowest GFR quartile (mean GFR 41 mL/min) faced significantly higher risks.
  • Adjusted analyses showed increased risk for myocardial infarction (RR 1.51) and death (RR 2.60) in the lowest GFR quartile.
  • These associations persisted even after accounting for coronary disease severity and treatment.

Conclusions:

  • Moderate renal failure independently elevates the risk of myocardial infarction and death.
  • This increased risk is evident irrespective of clinical variables, baseline coronary disease, or therapy.
  • Findings highlight the critical role of kidney function in cardiovascular outcomes.
Abstract

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