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Homologous telomere association of 19q in a female with premature ovarian failure
L Zahed1, N Darwiche, J R Batanian
1Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon. lailaz@aub.edu.lb
Abstract:
Premature ovarian failure (POF) may be due to a variety of genetic mechanisms. We report here, for the first time, telomere association of the long arms of chromosome 19, identified at low frequency (1%) in the peripheral blood cultures of a 30-year-old female with POF. Repeat cultures identified, in addition, the presence of 16q and 22q associations at a lower frequency (0.5%). These consistent observations are suggestive of a non-random event. Their association with POF may just be coincidental or may hypothetically explain it by an abnormal mechanism of chromosome separation, a constitutional telomere anomaly or an unidentified chromosome instability disorder.
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