Related Experiment Videos
Atopic allergy and delayed type hypersensitivity in Estonian children
1Allergy Centre, Children's Clinic of Tartu University Clinics, Estonia. kaja.julge@kliinikum.ee
Summary
In atopic children, immune responses to both Th1 and Th2 cells are elevated, not decreased as previously hypothesized. This suggests immune modulation rather than a simple imbalance in allergic conditions.
Area of Science:
- Immunology
- Allergy Research
- Pediatric Health
Background:
- Atopic diseases are often linked to a shift in T helper (Th) cell balance towards Th2 populations.
- However, both Th1 and Th2 related disorders have seen an increase in Western communities.
Purpose of the Study:
- To investigate the delayed type hypersensitivity (DTH) response in atopic versus non-atopic children.
- Study conducted in a population with low prevalence of allergic disorders.
Main Methods:
- Skin prick tests (SPT) performed with egg white and common inhalant allergens.
- DTH response evaluated using Multitest CMI in 72 Estonian children aged 4-6 years.
Main Results:
- SPT-positive children showed a significantly higher frequency of response to diphtheria (55% vs. 26%).
- Greater induration size for diphtheria and tetanus DTH responses in SPT-positive children.
- Cumulative DTH induration size was significantly larger in SPT-positive children.
Conclusions:
- Findings do not support a Th1 decrease and Th2 increase hypothesis for atopic disease in this cohort.
- Results suggest immune modulation, with increased Th1 and Th2 responses in atopic subjects.