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[Clozapine-induced obsessive-compulsive disorder: a case report].

L Sánchez Bonome1, J M Barjau Romero, R de Lara Muñoz

  • 1Equipo de Salud Mental de La Línea, Cádiz, Spain.

Actas Espanolas De Psiquiatria
|October 10, 2002
PubMed
Summary
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Obsessive-compulsive behavior can emerge in patients treated with clozapine. This case study shows fluoxetine successfully treated these symptoms in a patient with schizoaffective disorder.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia and schizoaffective disorder.
  • Obsessive-compulsive symptoms (OCS) have been anecdotally reported in patients treated with clozapine since 1992.

Observation:

  • A 22-year-old male diagnosed with schizoaffective disorder developed new-onset obsessive-compulsive behaviors after initiating clozapine treatment.
  • The patient's schizoaffective disorder was previously managed with other medications before the introduction of clozapine.

Findings:

  • The emergence of obsessive-compulsive behaviors was directly linked to the initiation of clozapine therapy.
  • Treatment with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), effectively resolved the clozapine-induced obsessive-compulsive behaviors.

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Implications:

  • This case highlights a potential adverse effect of clozapine, necessitating careful monitoring for obsessive-compulsive symptoms.
  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine may be a viable treatment option for managing clozapine-induced obsessive-compulsive behaviors.