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Transcription activation: unveiling the essential nature of TFIID
Bo-Shiun Chen1, Michael Hampsey
1Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Current Biology : CB
|October 10, 2002
Abstract:
The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes.