Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trapping the sensor.

Eitan Reuveny1

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

Neuron
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

Physical constraints in the gating canal of voltage-gated potassium channels dictate the speed of channel opening. This movement of the S4 domain influences ion conduction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.

Nature aging·2026
Same author

One-shot design elevates functional expression levels of a voltage-gated potassium channel.

Protein science : a publication of the Protein Society·2024
Same author

Store-operated Ca<sup>2+</sup> entry regulatory factor alters murine metabolic state in an age-dependent manner via hypothalamic pathways.

PNAS nexus·2023
Same author

Modern venomics-Current insights, novel methods, and future perspectives in biological and applied animal venom research.

GigaScience·2022
Same author

Production of recombinant venom peptides as tools for ion channel research.

Methods in enzymology·2021
Same author

Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.

The Journal of general physiology·2021
Same journal

Dynamic coordination and segregation mechanisms in higher cortex for parallel task processing.

Neuron·2026
Same journal

Higher-order thalamic bursts are drivers of attention control.

Neuron·2026
Same journal

Composing trajectories for rapid inference of navigational goals.

Neuron·2026
Same journal

Peri-head distance coding in the mouse brainstem.

Neuron·2026
Same journal

A two-timepoint framework for sensitive and specific single-cell activity screening.

Neuron·2026
Same journal

From first impressions to bonds: The neural dynamics of social relationships.

Neuron·2026
See all related articles

Area of Science:

  • Molecular and Cellular Biology
  • Biophysics
  • Neuroscience

Background:

  • Voltage-gated ion channels are crucial for cellular electrical signaling.
  • The S4 domain acts as the voltage sensor, detecting changes in membrane potential.
  • Conformational changes in the S4 domain control channel gating and ion flow.

Discussion:

  • The study investigates the role of the 'gating canal' in modulating channel kinetics.
  • Physical limitations within this crevice influence the speed of S4 domain movement.
  • This mechanism provides insights into the fine-tuning of electrical excitability.

Key Insights:

  • The physical constraints of the gating canal are a key determinant of voltage-gated potassium channel opening speed.
  • Slower or faster gating is directly linked to the geometry of the S4 pathway.

Related Experiment Videos

  • This finding elucidates a novel mechanism controlling neuronal excitability.

    • Outlook:

    • Further research can explore how mutations affecting the gating canal impact channel function in disease.
    • Understanding these constraints may lead to the development of novel therapeutics targeting ion channel activity.
    • This work opens new avenues for studying the biophysics of voltage-gated channels.