Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Executive control during episodic retrieval: multiple prefrontal processes subserve source memory.

Ian G Dobbins1, Heather Foley, Daniel L Schacter

  • 1Martinos Center for Biomedical Imaging, MGH/MIT/HMS, Charlestown, MA 02129, USA. ian@nmr.mgh.harvard.edu

Neuron
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissociable structural and molecular pathways of age-related change in sustained attention.

bioRxiv : the preprint server for biology·2026
Same author

Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.

Epilepsy & behavior : E&B·2026
Same author

Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Gaze patterns reveal attention-based modulation of lure discrimination.

Cognition·2026
Same author

Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.

Molecular neurodegeneration·2026
Same author

Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.

bioRxiv : the preprint server for biology·2026

This study reveals distinct brain regions in the left prefrontal cortex (PFC) involved in recalling specific memory details (source memory). These areas are separate from those used for simply recognizing items (item memory).

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Human Memory

Background:

  • Memory recognition involves both item memory (familiarity) and source memory (contextual details).
  • Cognitive theories propose source memory relies on controlled cue specification and monitoring.
  • Previous functional imaging studies implicated the left prefrontal cortex (PFC) in these processes.

Purpose of the Study:

  • To investigate the specific nature and anatomical segregation of cognitive processes within the left PFC during source memory retrieval.
  • To differentiate the neural substrates underlying item memory versus source memory.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to observe brain activity during memory tasks.
  • Participants engaged in tasks designed to elicit both item and source memory retrieval.

Related Experiment Videos

  • Analysis focused on identifying distinct response patterns in the left PFC.

    • Main Results:

    • Distinct left PFC response patterns were identified: anterior ventrolateral for cue specification, posterior dorsolateral and frontopolar for recollective monitoring, and posterior ventrolateral for phonological rehearsal.
    • These specific control process activations were unique to source memory retrieval.
    • Activations for cue specification and recollective monitoring were absent during item memory and independent of retrieval success.

    Conclusions:

    • The attempt to recollect episodic details engages multiple, anatomically segregated control processes within the left PFC.
    • These findings provide neural evidence for distinct cognitive mechanisms differentiating item and source memory.
    • The left PFC plays a crucial role in the controlled retrieval of contextual memory information.